• The goal of this study was

  2018-10-20

  

  The goal of this study was to identify an additional cell-surface marker that, when combined with CD133, could further distinguish and enrich PCFUs. Cell surface markers that were previously known to enrich non-pancreas progenitor cells, including CD71 (transferrin receptor), were screened. CD71 tra

• To the best of our knowledge

  2018-10-20

  

  To the best of our knowledge, this is the first study to characterize H3K27me3 and H3K4me3 re-patterning accompanying cardiac reprogramming. Recently, it was reported that iPSC reprogramming is characterized by global loss of H3K27me3 in the beginning and later restoration of H3K27me3 at selected si

• AL 8697 br Mat http www RO

  2018-10-20

  

  Material andmethods Results anddiscussion Conclusions Here we report a comprehensive and unique transcriptomic study of the kinetics of gene AL 8697 during ASC adipogenesis in vitro. Despite the limitation of the study design including the use of relatively late passage ASCs and the lack of

• br Conclusion While our in vivo data show that

  2018-10-20

  

  Conclusion While our in vivo data show that Nilotinib blocks fibrogenesis in the context of skeletal muscle regeneration, our in vitro model provides evidence that mesenchymal progenitor EZ Cap Reagent AG (3\' OMe) prompt the expansion of tissue-specific stem cells, strengthening the notion that

• Studying the regulatory role of FGF signaling

  2018-10-20

  

  Studying the regulatory role of FGF signaling in mammalian neural development primarily focuses upon the VZ of the neocortex (after neural tube formation, discussed above), whereas its earlier role in neural induction is less explored. This may be due to the inaccessibility of embryonic tissues at t

• The following are the supplementary data related to this

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgments The authors wish to thank Dr. K. Inoue for the S100β/GFP-TG rats, Dr. A.F. Parlow and the NIDDK for the protease inhibitor against pituitary hormones, Dr. S. Tanaka at Shizuoka University for the antibody against

• Although there is strong clinical support for

  2018-10-20

  

  Although there is strong clinical support for developing cellular therapies, and the use of such therapies is already reaching clinical translation (Götherström et al., 2014), ethical issues associated with the collection and use of fetal tissue for research and therapy still remain. Concerned polit

• Although WNT signaling plays a prominent role in A

  2018-10-20

  

  Although WNT signaling plays a prominent role in A/P patterning of the neural tube, few studies have extensively examined the influence of WNT on the A/P positional identity of hPSC-derived NPCs and neurons. To date, most studies have relied on FGF8 (Yan et al., 2005; Yang et al., 2008) or retinoic

• kainate receptors Main Text br Acknowledgments The

  2018-10-20

  

  Main Text Acknowledgments The authors would like to thank all delegates for their input into the workshops that led to the contents of this white paper (Table S2). Introduction The type II clustered regularly interspaced short palindromic repeat (CRISPR) systems and the associated Cas9 nucle

• Direct cell reprogramming technology is

  2018-10-20

  

  Direct cell-reprogramming technology is based on the dominant action of cell-lineage transcription factors (TFs) in converting adult somatic cells into different cell types (Graf and Enver, 2009). This technique represents a promising avenue in the field of regenerative medicine, with the potential

• br Experimental Procedures br Acknowledgments

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction Spermatogonial stem Retigabine dihydrochloride (SSCs) give rise to the spermatogenesis that endures throughout the life of male animals (de Rooij and Russell, 2000; Meistrich and van Beek, 1993). SSCs reside in a special microenvironment

• One difficulty in deriving EpiSCs is the need for

  2018-10-20

  

  One difficulty in deriving EpiSCs is the need for microdissection of small postimplantation embryos. The original protocols used only the epiblast layer separated from the surrounding visceral endoderm (VE) tissue as a source of the cell lines. The overall efficiency of EpiSC derivation from epiblas

• The following are the supplementary data related

  2018-10-20

  

  The following are the supplementary data related to this article. Conflict of interest Introduction Mammalian eyes contain retinal stem cells (RSCs) that are capable of proliferating and differentiating into all of the cell types of the neural retina as well as the retinal pigmented epitheliu

• In this study lentiviral vectors were used to ablate

  2018-10-20

  

  In this study, lentiviral vectors were used to ablate CXCR4 and/or CXCR7 expression using shRNAs, and the derived hiPSC-CMs were tested for phenotypic and functional properties due to gene knockdown. Gene expression and flow cytometry studies confirmed the cardiomyocyte phenotype of the differentiat

• TAU fragments carry an apoptosis

  2018-10-20

  

  TAU fragments carry an apoptosis-inducing activity, which is further potentiated when mdm2 inhibitor are exposed to TAU fragments carrying the N279K mutation (Fasulo et al., 2005). In addition, overexpression of full-length TAU carrying the N279K or the V337M mutation resulted in induction of apopto

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