The following are the supplementary data related

2018-10-20

The following are the supplementary data related to this article. Conflict of interest Introduction Mammalian eyes contain retinal stem cells (RSCs) that are capable of proliferating and differentiating into all of the cell types of the neural retina as well as the retinal pigmented epitheliu

In this study lentiviral vectors were used to ablate

2018-10-20

In this study, lentiviral vectors were used to ablate CXCR4 and/or CXCR7 expression using shRNAs, and the derived hiPSC-CMs were tested for phenotypic and functional properties due to gene knockdown. Gene expression and flow cytometry studies confirmed the cardiomyocyte phenotype of the differentiat

TAU fragments carry an apoptosis

2018-10-20

TAU fragments carry an apoptosis-inducing activity, which is further potentiated when mdm2 inhibitor are exposed to TAU fragments carrying the N279K mutation (Fasulo et al., 2005). In addition, overexpression of full-length TAU carrying the N279K or the V337M mutation resulted in induction of apopto

We previously discovered that ATM

2018-10-20

We previously discovered that ATM, in addition to serving many roles in cell-cycle regulation and DNA damage response, also functions as a key epigenetic regulator in neurons, likely underlying the ataxic symptoms as well as neurodegeneration. ATM indirectly regulates nuclear-cytoplasmic shuttling o

Cardiac MRI was performed to

2018-10-20

Cardiac MRI was performed to assess potential changes in cardiac function due to teratoma growth. For this, a subacute model with cell delivery 4 days after ischemia reperfusion injury was chosen since functional improvements following the transplantation of human ESC-CMs have been reported for this

br Experimental Procedures br Author Contributions br Introd

2018-10-20

Experimental Procedures Author Contributions Introduction Bone-marrow-derived mesenchymal stromal beta amyloid (BM-MSCs) have been reported to secrete neurotrophic cytokines as well as a range of pro-inflammatory cytokines, chemokines, and other soluble growth factors (Nakano et al., 2010;

Aside from the benefits of the actual protocol

2018-10-20

Aside from the benefits of the actual protocol, our method also results in hiNSCs with multiple favorable properties including a seemingly endless capacity for self-renewal. hiNSC colonies grown on MEF feeders are approximately 50% positive for proliferation marker Ki67, a characteristic that does n

We have confirmed that established iPS RPE

2018-10-20

We have confirmed that established iPS-RPE cells constitutively express MHC-I but not MHC-II. However, the cytokines produced acutely in response to immune rejection may upregulate RPE MHC-II expression, as seen in vitro. This upregulation may be sufficient to initiate a recognition response in vivo

Here we attempted to reprogram highly fluorescence activated

2018-10-20

Here, we attempted to reprogram highly fluorescence-activated cell sorting (FACS)-purified (100% purity) leukemia blasts from three subtypes of B-ALL, t(4;11)/MLL-AF4+, t(1;11)+MLL-EPS15+, and t(12;21)/ETV6-RUNX1 B-ALL, to establish novel iPSC-based disease models to address the developmental impact

Hello world!

2018-07-29