• br Conclusion br List of abbreviations br Acknowledgment The

  2023-11-22

  

  Conclusion List of abbreviations Acknowledgment The studies performed by our laboratory and presented in this review were supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, (KAKENHI 17590618 [to H.I.] and KAKENHI 22249017 [to Y.Y.]), and the Japanese S

• br Results br Discussion Autophagy is considered as

  2023-11-22

  

  Results Discussion Autophagy is considered as an important process in physiological and pathological ovarian function. It is related mainly to follicular atresia and CL regression (for review see [20]). However, an involvement in luteal cell survival is also proposed [21], [22]. The present st

• A unique finding in this study is that LO

  2023-11-22

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic TCS 359 for substrate, can regulate CREB phosphoryation in the context of Alzheimer's d

• Exposure to cisplatin with ATR inhibitor resulted in an

  2023-11-22

  

  Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre

• br Concluding remarks It is clear that a

  2023-11-22

  

  Concluding remarks It is clear that a disordered l-arginine homeostasis by changes in arginase, NOS and ADMA activity and expression, is not only vital in the chronic airway diseases, Epoxomicin and COPD, but also seems to play an important role in many co-morbidities. Unknown, however, is wheth

• br Introduction Sustained over activation of neurohormonal s

  2023-11-22

  

  Introduction Sustained over-activation of neurohormonal systems is a hallmark in the pathophysiology of cardiac dysfunction following myocardial infarction (MI) and heart failure (HF). Inhibitors of the renin-angiotensin AZ20 australia system (RAAS) constitute cornerstones of pharmacotherapy for

• In our study we provide evidence

  2023-11-22

  

  In our study we provide evidence for the existence of an endosome-lysosomal pathway for the proteolytic degradation of AR triggered by its interaction with the ESCRT-I component TSG101. The following findings of this study support this notion: (1) We showed that TS101 interacts with endogenous or ec

• Some of previous immunohistochemical studies have compared t

  2023-11-22

  

  Some of previous immunohistochemical studies have compared the levels of AR expression in low-grade versus high-grade and/or non-muscle-invasive versus muscle-invasive tumors. There was a significant or marginal decrease (Boorjian et al., 2004, Miyamoto et al., 2012b, Rau et al., 2011, Shyr et al.,

• Luo Dehm Raj Luo Attard Balk Bevan Burnstein Cato Cherkasov

  2023-11-22

  

  Luo, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong, Gao, Gleave, Heemers, Kanayama, Kittler, Lang, Lee, Logothetis, Matusik, Plymate, Sawyers, Selth, Soule, Tilley, Weigel, Zoubeidi, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong,

• br Material and methods br Results br Discussion Nimodipine

  2023-11-22

  

  Material and methods Results Discussion Nimodipine administration inhibited the level of AMP-activated protein kinase (AMPK) phosphorylation, a sensor of cellular energy status that directs metabolic CO-1686 to support cellular growth and survival. CCH influences the oxygen and glucose sup

• br Perspective AA LA and other PUFAs

  2023-11-22

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• br Results and discussion br Conclusion The tyrosine

  2023-11-22

  

  Results and discussion Conclusion The tyrosine kinase ALK represents one of the most successful molecular targets for the development of precise medicine to treat stratified subgroups of cancer patients. Three generations of ALK inhibitors have been awarded the FDA's approval or are being exte

• Shikonin Our previous study revealed expression of

  2023-11-21

  

  Our previous study revealed expression of AhR in human parotid gland in cytoplasm of striated duct Shikonin (Drozdzik, Kowalczyk, Urasińska, & Kurzawski, 2013). In a further study we observed regulation of AhR expression and function by its specific inducer, i.e. 2,3,7,8-tetrachlorodibenzo-p-dioxin

• Constitutive tyrosine kinase activity of BCR ABL fusion

  2023-11-21

  

  Constitutive tyrosine kinase activity of BCR/ABL fusion genes causes uncontrolled cell growth and is also thought to be responsible for a variety of changes in normal cellular functions like differentiation, adhesion, migration and apoptotic response in CML. Therefore it is important to know the exp

• Pioneering studies on the immunomodulatory role

  2023-11-21

  

  Pioneering studies on the immunomodulatory role of adenosine date back to the early ‘70 s of last century (Fig. 1), when the critical role of this nucleoside in shaping the development and the activity of several immune cell populations was first established [[18], [19], [20], [21], [22]]. This then

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