• In this study we provide biochemical and immunohistochemical

  2022-02-04

  

  In this study we provide biochemical and immunohistochemical evidence for the localization of the glycine transporter GLYT1 in synaptic vesicles. Previously, it was thought that GLYT1 was exclusively a glial protein (Zafra et al., 1995a). However, due to a partial discrepancy between mRNA and protei

• We focus here on the historical discoveries

  2022-02-03

  

  We focus here on the historical discoveries that led to the development of the concept of ferroptosis. Ferroptosis is defined as an iron-dependent form of regulated cell death, which occurs through the lethal accumulation of lipid-based reactive oxygen species (ROS) when glutathione (GSH)-dependent

• In the current study we report the

  2022-02-03

  

  In the current study, we report the properties of P. anserina mutants carrying mutations in a gene encoding the bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). This enzyme catalyzes two opposite reactions (Pilkis et al., 1995, Rider et al., 2004): synthesi

• Yap and Taz may regulate epicardial

  2022-02-01

  

  Yap and Taz may regulate epicardial cell proliferation, EMT, and fate determination via multiple mechanisms. In this study, we provide evidence that Yap/Taz function in part by directly modulating Tbx18 and Wt1 expression. Members of the T-box family of transcription factors regulate a variety of d

• In recent years the Hippo signaling

  2022-02-01

  

  In recent years, the Hippo signaling pathway has emerged as an important regulator balancing cell proliferation and differentiation [[5], [6], [7]]. The pathway components, first described in the fruit fly Drosophila melanogaster, are highly conserved across different phyla [6]. The signaling pathwa

• Bile acids synthesized in the liver are

  2022-02-01

  

  Bile acids synthesized in the liver are secreted into the intestinal tract to facilitate the digestion and Q-VD-Oph of nutrients. Most bile acids are reabsorbed by the ileum and are transported back to the liver via the portal blood circulation. Recently, bile acids have also been considered as hep

• br S proteins and HBV induced

  2022-02-01

  

  S proteins and HBV-induced autophagy HBV surface proteins (S proteins or HBs) are reported to trigger HBV-induced autophagy by inducing ER stress and UPR in host tnf alpha inhibitors [22]. HBx and HBV-induced autophagy HBx is a multifunctional viral protein. It can regulate virus replication,

• br Acknowledgements br Funding This work was

  2022-02-01

  

  Acknowledgements Funding: This work was supported by the Instituto Nacional de Biomedicina do Semiárido (INCT-IBISAB-CNPq), Edital MCT/CNPq N° 014/2010 - Universal and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Introduction Guanylin and uroguanylin are small, heat-

• br Pathophysiology of glaucoma Glaucoma

  2022-02-01

  

  Pathophysiology of glaucoma Glaucoma is a group of optic neuropathies defined by progressive degeneration of RGCs and their Sunitinib in the optic nerve, which leads to irreversible loss of vision [3,8,9]. RGC degeneration is often significantly advanced before changes in visual acuity and evide

• br GSNOR activity and functions

  2022-02-01

  

  GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en

• It is generally considered that elevated blood glucose

  2022-01-31

  

  It is generally considered that elevated blood glucose due to insulin resistance is an important factor in islet compensation to high fat feeding [27]. However, we have shown recently that insulin resistance induced in mice by hydrocortisone injection provokes significant islet nisin in the absence

• br STAR Methods br Introduction Secretase is a

  2022-01-31

  

  STAR★Methods Introduction γ-Secretase is a membrane-embedded proteolytic complex belonging to a diverse family of intramembrane-cleaving proteases and is composed of four integral membrane proteins: presenilin (PS), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer

• The NGS of six Southern

  2022-01-31

  

  The NGS of six Southern Brazil patients revealed three different variants: c.472C > T (p.Arg158Trp); c.958G>A (p.Gly320Arg) and c.986T>C (p.Leu329Pro) (Table 2). The amino acids involved in these substitutions were evolutionarily conserved in different species (Fig. 1B). The amino motilin receptor

• The synthesis of substituted pyrimidinone carboxamides is ou

  2022-01-31

  

  The synthesis of 2-substituted pyrimidinone carboxamides – is outlined in , . Treatment of readily accessible nitriles with N-methylhydroxylamine hydrochloride in the presence of AS-703026 synthesis provided the adducts , which were subsequently reacted with diethyl acetylenedicarboxylate to affor

• SCR7 Surface enhanced Raman spectroscopy SERS is one

  2022-01-31

  

  Surface-enhanced Raman spectroscopy (SERS) is one of the most powerful and ultra-sensitive analytical tools, which has been widely applied to food security analysis and many other fields (Craig, Franca, & Irudayaraj, 2013; Gukowsky, Xie, Gao, Qu, & He, 2018; Qi et al., 2013; Zhang et al., 2015). For

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