• br ET Antagonist for the Future Macitentan and Atresentan

  2021-07-28

  

  ET Antagonist for the Future: Macitentan and Atresentan Macitentan is an insurmountable antagonist, resulting from structure-activity studies to improve the efficacy and tolerability of bosentan, and gained approval in the United States in 2013 for the treatment of PAH. Actelion describes the com

• br Effects of culture conditions on drug induced

  2021-07-28

  

  Effects of culture conditions on drug-induced gene Histamine Phosphate in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that are m

• br Asb Proteins and Mitochondrial

  2021-07-28

  

  Asb Proteins and Mitochondrial Function Mitochondria are intracellular organelles in eukaryotic q vd oph and are the main sites of oxidative phosphorylation and ATP production. In addition, mitochondria serve as signal transduction docking stations in pyroptosis and regulate a plethora of proces

• Mulan protein level is regulated with

  2021-07-28

  

  Mulan protein level is regulated with conditions that stimulate mitophagy such as treatment of Norethindrone with CCCP [12]. We found that exogenously expressed GFP-GABARAP and RFP-Mulan could co-precipitate and co-localize in mammalian cells and the degree of co-localization increased when the cel

• br Introduction Vitis vinifera L is one of the most

  2021-07-28

  

  Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat

• The authors gratefully acknowledge financial support from th

  2021-07-28

  

  The authors gratefully acknowledge financial support from the State of São Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo), grants 2013/07600-3 and 2013/25658-9, and the National Council for Scientific and Technological Development (CNPq, Conselho Nacional de

• br Role of CRF receptors

  2021-07-28

  

  Role of CRF1 receptors in the BNST in stress-induced relapse to cocaine seeking The seminal work of Stewart and co-workers [19] showed that rats that have extinguished their auto-administration of different drugs of abuse relapse to drug-seeking behaviour when exposed to footshock, even after a 4

• To extend these toxicity minimization

  2021-07-28

  

  To extend these toxicity minimization strategies to 3D tissues, a more complicated mass transfer model is necessary to account diffusion in the interstitial space, as well as transport across cell membranes. Until recently, tissue mass transport in cryobiology was modeled using classic spatially dep

• br Conclusion br Declaration of interest br

  2021-07-27

  

  Conclusion Declaration of interest Introduction Glyphosate [N-(phosphonomethyl)glycine] is the main active ingredient in one of the most widely used herbicides in the world. The commercially used concentrations of glyphosate range from 1% for domestic use to 41% for conventional agricultura

• We report here that ESCL protein exhibits a temporal

  2021-07-27

  

  We report here that ESCL protein exhibits a temporal expression profile that is complementary to that of ESC, including substantially higher levels of expression during larval and adult stages than embryogenesis. We show that ESCL, like ESC, binds directly to E(Z) via its WD repeats and is physicall

• br Discussion br Conflicts of interest

  2021-07-27

  

  Discussion Conflicts of interest Acknowledgment Introduction Ewing's sarcoma (EWS) is a bone cancer arising mostly in children. In 1921, EWS was originally described as “diffuse endothelioma of bone” by Dr. James R. Ewing, an American pathologist [1]. In 1992, Ewing sarcoma breakpoint re

• br Experimental Procedures br Author Contributions br Acknow

  2021-07-27

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Estrogen-related receptors (ERRα, ERRβ, and ERRγ) are orphan nuclear receptors whose physiological ligands have not yet been identified. Although ERRs are closely related to estrogen receptors (ERs) they do not res

• To our knowledge immunohistochemical analysis for proGRP was

  2021-07-27

  

  To our knowledge, immunohistochemical analysis for proGRP was done in 5 cases [9], [10], [17], [18]. Takagi-Takahashi et al. reported that the tumor NS 11394 synthesis were positive for proGRP in one case [9]. Yamaguchi et al. also showed that tumor cells in two patients of ES/PNET with elevated se

• Here we report that ILC s sensed

  2021-07-27

  

  Here, we report that ILC3s sensed oxysterols through GPR183, which was highly expressed by LTi-like ILC3s. 7α,25-OHC-synthesizing enzymes were produced by fibroblastic stromal lxr agonists found in intestinal lymphoid structures, and the GPR183 ligand 7α,25-OHC acted as a chemoattractant for ILC3s.

• Autophagy is a degradation pathway existing

  2021-07-27

  

  Autophagy is a degradation pathway existing in all eukaryotic organisms. It is the main system for the degradation of bulk cytoplasmic components in cells (Feng et al., 2014), but it also plays a crucial role in other processes, as immunity (Wileman, 2013), mitochondrial (Dengjel and Abeliovich, 201

16043 records 611/1070 page Previous Next First page 上5页 611612613614615 下5页 Last page