• There are studies that evaluated

  2021-04-21

  

  There are studies that evaluated the stability of CMV DNA over different periods of time. A study that evaluated stability of EDTA plasma samples stored over a 21-day period at 4 °C found no significant change in the viral loads or any trend of continued DNA degradation [9]. Another study did not fi

• Exon encodes a section of the extracellular ligand

  2021-04-21

  

  Exon 3 encodes a section of the extracellular ligand-binding domain and two variants in the 5′ region were first identified in Drosophila melanogaster (Semenov and Pak, 1999). These variants were initially termed modules 1 and 2 and correspond to exons 3a and 3b, respectively. To date, exon 3 altern

• br Diverse functions of ERK pathway Same as the other

  2021-04-20

  

  Diverse functions of ERK pathway Same as the other MAPK cascades, the ERK pathway is activated by several extracellular stimuli and different internal routes. ERK vitally tunes the function of various substrates in all cellular components; the nucleus, cytoplasm, membranes and the cytoskeleton. E

• In our previous research we have

  2021-04-20

  

  In our previous research, we have focused on the discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Numbers of biphenyl-aryl urea incorporated with salicylaldoxime including BPS-7 have been developed as potent and selective VEGFR-2 inhibitors (Fig. 3) [12], [13], [14], [15], [16], [1

• br Activatable photoacoustic probes Photoacoustic PA imaging

  2021-04-20

  

  Activatable photoacoustic probes Photoacoustic (PA) imaging is a recently developed technique [47]. The imaging approach uses probes that absorb a pulsed laser beam and convert light energy into acoustic signals. It combines the advantages of the high sensitivity offered by optical imaging and th

• Introduction Obesity constitutes a global healthcare problem

  2021-04-20

  

  Introduction Obesity constitutes a global healthcare problem and has many adverse effects on the cardiovascular function [1,2]. Recently, the perivascular adipose tissue (PVAT) has emerged as a relevant fat depot for cardiovascular risk and as a potential trigger in vascular dysfunction. Indeed, PV

• While we previously demonstrated that TraG is

  2021-04-20

  

  While we previously demonstrated that TraG is inhibited by specific transglycosylase inhibitors and that enzymatic activity is strongly reduced upon mutation of the potential catalytic core (Arends et al., 2013), the enzymatic mechanism of both domains was not assigned. Here, by mass spectrometry an

• Introduction CYP is a superfamily of heme containing monooxy

  2021-04-20

  

  Introduction CYP450 is a superfamily of heme-containing monooxygenases, many of which are expressed in the liver, and they are significant phase-I avibactam receptor in drug metabolism and detoxification. There are three subfamilies (CYP1, CYP2 and CYP3) that are mainly involved in the metabolism

• ELUXA HM EMSI is an ongoing

  2021-04-20

  

  ELUXA 1 (HM-EMSI-202) is an ongoing pivotal Phase II global clinical trial, designed to further investigate the efficacy and safety of Olmutinib in patients T790M-positive NSCLC with acquired resistance after first-line EGFR TKIs. Primary endpoint is ORR according to RECIST 1.1, while secondary endp

• br Materials and methods br Results br Discussion Anti EGFR

  2021-04-20

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

• br Methods br Results br Discussion Skin biopsy and microneu

  2021-04-20

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific YM201636 organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and Liguor

• br UVC induced DNA damage

  2021-04-20

  

  UVC-induced DNA damage: a model to study DNA damage tolerance The UV components of sunlight that reaches the Earth surface are one of the most carcinogenic agents humans are exposed to, and the leading cause of skin cancer [4,12]. UV light causes different types of DNA damage through indirect and

• Recently it was reported that Crm

  2021-04-20

  

  Recently, it was reported that Crm1 is linked to spindle pole body (SPB) by Spc72 in EW-7197 yeast [9]. Spc72 and Spc110 are two specific receptors of γ-tubulin complex (Tub4), which target Tub4 to SPB and mediate the nucleation of microtubules from SPB [20]. It was found that disrupting the interac

• Cryoprotectant equilibration and the response to ice

  2021-04-19

  

  Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, cannabinoid receptors are typically assumed to have uniform, spatially independent extracellular concentra

• br Materials and methods br Results br Discussion One

  2021-04-19

  

  Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and inhibitor chemistry were found to express CK2α. The robust

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