• br Benefits and risks of

  2021-06-02

  

  Benefits and risks of traditional combined oestrogen–progestogen HRT regimens Combined oestrogen–progestogen regimens were developed to reproduce the short- and long-term benefits of oestrogen replacement therapy (ERT) and to simultaneously provide appropriate protection against oestrogen-related

• br Enzyme activations Activated proteinases

  2021-06-02

  

  Enzyme activations Activated proteinases can unleash a deluge of tissue damage (Zucker et al., 2009). Once activated, the essential enzymes such as serine proteases and cysteine proteases cannot discriminate between self and non-self, burning away self-tissues (Chien et al., 2009, Laskar et al.,

• br Conclusion The past few

  2021-06-02

  

  Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte

• Dyngo-4a br Experimental Procedure br Acknowledgment This

  2021-06-01

  

  Experimental Procedure Acknowledgment This work was supported by Ministry of Education, Singapore (MoE Tier-2) grant (R-154-000-625-112) and R154-000-A72-114 (AcRF Tier 1 grant) respectively. We acknowledge the Advanced Photon Source Beamline 24-ID-C, Argonne National Laboratory, USA. D.N. is

• br Discussion and conclusion Ubiquitination and deubiquitina

  2021-06-01

  

  Discussion and conclusion Ubiquitination and deubiquitination have emerged as important mechanisms involved in p53 management. This review revealed that various DUBs can regulate p53 or p53-Mdm2-MdmX networks. Herein, we reviewed the current progress made toward elucidating the complexities in th

• Interestingly we observed that T D islet

  2021-06-01

  

  Interestingly, we observed that T2D islet hydralazine hcl synthesis have lower DPP-4 expression, as compared to ND cells (Fig. 1, Fig. 2). Previously, a reduced activity of this peptidase was observed in human T2D islet lysates (Omar et al., 2014). As mentioned above, GLP-1 is also produced by isle

• br Methods br Results br Discussion Preclinical data indicat

  2021-06-01

  

  Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the ARCA EGFP mRNA sale with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not s

• br Transparency document br Acknowledgements This work

  2021-06-01

  

  Transparency document Acknowledgements This work was supported by research grant G092715N of the Research Foundation Flanders (FWO). The authors are indebted to Drs. V. Baekelandt and E. Lobbestael (Research Group for Neurobiology and Gene Therapy, KU Leuven) for stimulating discussions and he

• lamotrigine Several highly potent CysLT receptor antagonists

  2021-06-01

  

  Several highly potent CysLT1 receptor antagonists with large structural lamotrigine have been developed. Beyond antagonists with structures analogous to cysteinyl leukotrienes, other subclasses comprise: (a) hydroxyacetophenones, (b) indoles and indazoles, (c) quinolines, benzothiazoles, and thiazo

• T cell infiltration is an

  2021-06-01

  

  T cell infiltration is an important predictive biomarker for the PD-1 blockade, and it is closely associated with a good prognosis. In our study, we found that T cells were low and exhausted within the tumor microenvironment and were distributed in the tumor margin. Anti-PD-1 treatment reduced PD-1

• RQ What are the different factors that influence the decisio

  2021-06-01

  

  RQ2: What are the different factors that influence the decision to choose among different component origins? In total eleven factors grouped into three high-level themes that influence the decision to choose a component origin were identified. The project metrics factors are: time, cost, effort and

• To further investigate mechanisms of rXCI

  2021-05-31

  

  To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these S-Adenosylhomocysteine undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonst

• br Conclusion br Experimental NMR spectra were

  2021-05-31

  

  Conclusion Experimental NMR spectra were recorded on a Jeol spectrometer at either 270 or 400 MHz for 1H spectra and either 68 or 100 MHz for 13C spectra. All chemical shifts are quoted in ppm relative to tetramethylsilane. In the assignment of signals the abbreviation DHN is used for 2,3-dihy

• There have been reports regarding the use of

  2021-05-31

  

  There have been reports regarding the use of enolases as novel vaccine candidates for A. suum, S. suis, T. pisiformis and T. multiceps on account of this enzyme class's critical role in plasminogen activation and migration across tissue barriers (Chen et al., 2012; Zhang et al., 2009; Zhang et al.,

• br DDR receptor and MMP

  2021-05-31

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt

16172 records 650/1079 page Previous Next First page 上5页 646647648649650 下5页 Last page