• In WHO Task Force on Developing Health Systems

  2019-04-29

  

  In 2012, WHO Task Force on Developing Health Systems Guidance proposed a series of processes and tools to support evidence-informed decisions about health system interventions. Many of the processes were adapted from clinical evidence-based medicine and an insightful commentary by Peters and Bennet

• br Advance disease clinical trials In patients with

  2019-04-29

  

  Advance disease clinical trials In patients with bone metastatic disease, studies have shown BPs to decrease the incidence of skeletal related events, delay the onset of these complications, and reduce bone pain [59–61]. There is also evidence that they may improve overall survival in subgroups o

• br Future perspectives Identification of LOX as a

  2019-04-29

  

  Future perspectives Identification of LOX as a modulator of the ECM to form pre-metastatic niches and subsequently bone metastasis arose as we were investigating the hypoxia tumour secretome using existing patient cohort data and cutting edge proteomics. Although condoned by some researchers as “

• br Discussion Both hypokalemia and TC are known to

  2019-04-29

  

  Discussion Both hypokalemia and TC are known to cause QT prolongation and TWA. In spite of prolonged hypokalemia, the alternans of J-wave amplitude and TWA changed dramatically with the time course of the patient׳s recovery from myocardial stunning, which suggested that hypokalemia was not likely

• Regarding patients with a lower

  2019-04-29

  

  Regarding patients with a lower annual risk of thromboembolism ( Management of direct acting oral anticoagulants during pacemaker insertion There are less data available regarding management of DOACs peri-procedurally. The general principle is that PM/ICD implantation is considered a low bleeding

• br Conflict of interest br Case presentation

  2019-04-29

  

  Conflict of interest Case presentation A 41-year-old man with a history of palpitations refractory to multiple antiarrhythmic agents for several weeks was referred to our department. A 12-lead electrocardiogram (ECG) demonstrated incessant narrow QRS complex tachycardia (cycle length of 580ms)

• As part of this comprehensive approach it is impossible to

  2019-04-29

  

  As part of this comprehensive approach, it is impossible to neglect the importance of infection as an underlying and contributing cause of maternal and newborn mortality. Deaths due to infection occur mainly through sepsis—a potentially life-threatening condition caused by a dysregulated host respon

• Friberg et al have indicated that the CHA

  2019-04-28

  

  Friberg et al. [17] have indicated that the CHA2DS2-VASc score is superior to the CHADS2 score in terms of stroke risk stratification, and the risk of stroke is extremely low among patients with a CHA2DS2-VASc score of in whom antithrombotic therapy is not beneficial and may even increase the risk o

• br Methods br Results br Discussion br Conclusion

  2019-04-28

  

  Methods Results Discussion Conclusion Funding This work was supported by grants from the Ministry of Health, Labour, and Welfare of Japan (2010-145); a Grant-in-Aid for Scientific Research on Innovative Areas (22136011 A02, Aiba); a Grant-in-Aid for Scientific Research (C) (24591086 A

• br Future therapies The question of how understanding

  2019-04-28

  

  Future therapies The question of how understanding the cardiac dynamics can enable us to devise better pharmacotherapy for arrhythmia management persists. Numerous studies using animal models have demonstrated that the anti-arrhythmic actions of many drugs are in part mediated by their effects on

• La an cdota dialoga con el acto

  2019-04-28

  

  La anécdota dialoga con el acto de traducción que Mier y Rodríguez realizan de la novela de Chateaubriand y, de hecho, pueden pensarse, gracias a la disposición que Mier les da en el mismo capítulo de su escrito, como actos análogos que implican la toma de posesión y desviación de la voz del extranj

• br Diarrhoeal diseases are the second

  2019-04-28

  

  Diarrhoeal diseases are the second most common cause of deaths of children, killing more than 1·5 million children annually and infecting billions more. The recently released Global Action Plan for Pneumonia and Diarrhoea (GAPPD) is a comprehensive strategy document outlining plans to end preventa

• br Access to surgery remains inequitable worldwide

  2019-04-28

  

  Access to surgery remains inequitable worldwide, with 5 billion people lacking safe and affordable surgical and anaesthesia care when needed. Commission on Global Surgery was convened in 2013 to assess the state of surgery around the world, provide recommendations for improving access, and propose

• thyrotropin releasing hormone Another problem is that the in

  2019-04-28

  

  Another problem is that the indications of each drug differ among Asia-Pacific countries, and it thyrotropin releasing hormone is difficult to provide recommendations that are consistent with the indications in each country. For example, in Japan, the 3 novel OACs are indicated for “the prevention

• br Discussion Primary lymphoma of bone is a

  2019-04-28

  

  Discussion Primary lymphoma of bone is a rare disease, first described by Oberling in 1928 and he labeled it as reticulum cell sarcoma of bone because of the presence of characteristic reticulin fibers within the lesion [5]. This work was followed by Parker and Jackson and later by Ivin and Bosto

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