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How hypothermia induces the UPR and ER hormesis
2018-10-25
How hypothermia induces the UPR and ER hormesis is unknown. One possibility is that it is simply due to aberrant folding of as yet unknown proteins at low temperatures. Alternatively, hypothermia may induce cold shock proteins such as the RNA binding motif protein 3 (RBM3), which has recently been s
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Studies in itk and IL mice
2018-10-25
Studies in itk−/− and IL-15−/− mice show that the main functional differences between CD44loCD122lo and CD44hiCD122hi CD8+ T cell populations reside in NK receptor expression (Dubois et al., 2006). Upregulated NK receptors and strong antitumor capacity are also characteristic of CD8+ bcr-abl inhibit
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br Conflict of Interest Statement br Author Contributions N
2018-10-25
Conflict of Interest Statement Author Contributions N.M., K.N., M.G., R.J.O., and M.K. performed in vitro and in vivo experiments; N.M., H.D., and M.K., performed protein purification, crystallization, data collection, structure determination, and structural analyses; P.C., and J.D.H. carried
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First the genotype analysis was done under four inheritance
2018-10-25
First, the genotype analysis was done under four inheritance models: general genotype model (2 degrees of freedom), additive model (each copy of the minor allele alters the risk in an additive form), dominant model (a single copy of the minor allele is sufficient to modify the risk) and recessive mo
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Several iterations of the OSC were tested
2018-10-25
Several iterations of the OSC were tested before arriving at the design used in this article and the main research article [1]. The electrical design can be seen in Fig. 3. A custom PCB with the form factor of an Arduino shield was produced from the design seen in Fig. 4. The OSC has three main se
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br Acknowledgements This work was
2018-10-25
Acknowledgements This work was supported in part by the Centre for a Sustainable University (KNU) and by the Cluster of Excellence “Integrated Climate System Analysis and Prediction” (CliSAP-EXC177) funded through the German Science Foundation (DFG) (grant number CliSAP EXC177). Underlying RapidE
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br Experimental design materials and methods We selected
2018-10-25
Experimental design, materials and methods We selected the four cultivars that are most widely farmed for food processing purposes. ‘Toyoshiro’ is the most popular cultivar and provides the highest yield for processing purposes in Japan [1]. ‘Kitahime’, ‘Snowden’ and ‘Poroshiri’ are predominantly
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br Conflict of interest statement br Acknowledgements
2018-10-25
Conflict of interest statement Acknowledgements This research was supported by operating grants from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Canadian Institutes of Health Research (CIHR) to DA. Furthermore, additional support was provided by the Ontario
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The tensile properties of the
2018-10-25
The tensile properties of the two alloys at a wide range of strain rates have been investigated [16]. The tensile tests of the two alloys at low strain rate were performed on a standard tensile test machine. A split-Hopkinson tension bar (SHPT) was used for the tensile test at high strain rate. The
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br Introduction Darier disease is a rare autosomal dominant
2018-10-25
Introduction Darier disease is a rare, autosomal p2y receptor disease caused by a mutation on chromosome 12q23-24, which encodes for the sarcoplasmic/endoplasmic reticulum Ca(2+)-adenosine triphosphatase type 2 isoform (SERCA2) enzyme. This condition is characterized by abnormal keratinization o
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Some studies reported an increased risk of anxiety and depre
2018-10-25
Some studies reported an increased risk of anxiety and depression in acne vulgaris patients accompanied by an impairment of quality of life in comparison with healthy individuals, although some studies showed no difference. In this study, we evaluated the quality of life with an acne-specific index,
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All Zirconia slices were subjected
2018-10-25
All 60 Zirconia slices were subjected to artificial accelerated aging using autoclave [14] at 134 °c, 0.2 MPa for 5 h according to ISO standards 13356. Using the same intraoral spectrophotometer the values of CIELab coordinates from each specimen were recorded and translucency parameter (TP) was ca
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Intrinsic factors that induce neurogenesis include neurotrop
2018-10-24
Intrinsic factors that induce neurogenesis include neurotrophins and neuropeptides, which are released by neuronal activity. Two specific factors, neuropeptide VGF (non-acronymic) and Brain-Derived Neurotrophic Factor (BDNF) have received attention in the context of their contribution to either prol
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purchase CMX001 Cell adhesion molecules CAMs are transmembra
2018-10-24
Cell adhesion molecules (CAMs) are transmembrane proteins that are responsible for mediating adhesion of cells to other cells and/or the extracellular matrix via their extracellular domains, while their intracellular domain interacts with the cytoskeleton. Thus, CAMs provide a direct link between th
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caspase pathway These results with fresh non fractionated no
2018-10-24
These results with fresh, non-fractionated, not culture-expanded, adipose tissue-derived SVF are comparable with other two previously reported clinical series, using cultured adipose-derived ADSCs with controlled cell doses. The adipose tissue contains large populations of mesenchymal caspase pathwa
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